Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.40 |
| ▸ | USP2 | O75604 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492014 | 0.92 | BRAF (0.50) | BRAFCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1461857 | 0.88 | AURKA (0.53) | BRAFCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2233967 | 0.79 | AURKA (0.47) | BRAFCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9930824 | 0.78 | BRAF (0.75) | BRAFCYP2C9CSF1RRAF1 | |
| SCHEMBL9930489 | 0.77 | KDM4C (0.53) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL9930247 | 0.77 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL1461792 | 0.75 | AURKA (0.53) | BRAFCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9930354 | 0.74 | BRAF (0.49) | BRAFCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10251149 | 0.74 | BRAF (0.66) | BRAFCYP2C9CSF1RRAF1ERN1 | |
| SCHEMBL9930535 | 0.73 | BRAF (0.51) | BRAFCYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | BRAF 1/4885CYP1A2 2189/4885CYP3A4 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.