Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.51 |
| ▸ | AURKA | O14965 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | PRKCI | P41743 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2312296 | 0.91 | MAPT (0.48) | RPS6KB1AURKAMAPTERN1BRAF | |
| SCHEMBL9931440 | 0.85 | JAK2 (0.46) | RPS6KB1AURKAMAPTERN1BRAF | |
| SCHEMBL9931421 | 0.83 | MAPT (0.43) | RPS6KB1AURKAMAPTERN1BRAF | |
| SCHEMBL9931348 | 0.82 | MAPT (0.41) | RPS6KB1AURKAMAPTALDH1A1ERN1 | |
| SCHEMBL9931256 | 0.81 | ADORA1 (0.41) | MAPTERN1BRAF | |
| SCHEMBL9930629 | 0.81 | MAPT (0.44) | RPS6KB1MAPTALDH1A1ERN1BRAF | |
| SCHEMBL9930225 | 0.81 | CHRM4 (0.43) | RPS6KB1AURKAMAPTALDH1A1ERN1 | |
| SCHEMBL2236509 | 0.77 | BRAF (0.44) | RPS6KB1AURKAMAPTALDH1A1CYP1A2 | |
| SCHEMBL14574926 | 0.76 | RPS6KB1 (0.80) | RPS6KB1AURKAALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL9930988 | 0.75 | AURKA (0.43) | RPS6KB1AURKAMAPTKDM4EERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | RPS6KB1 315/4885AURKA 1013/4885MAPT 1082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.