Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.65 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 7/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 7/20 | 0.44 |
| ▸ | CCNC | P24863 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9968438 | 0.90 | SMO (0.52) | SMOPTPN11CDK8CDK19KMT2A | |
| SCHEMBL9932498 | 0.85 | SMO (0.65) | SMOKCNH2TSHRMAPTKMT2A | |
| SCHEMBL12841520 | 0.83 | SMO (0.44) | SMOPTPN11CDK8CCNCHDAC1 | |
| SCHEMBL9931789 | 0.82 | PTPN11 (0.43) | SMOPTPN11KMT2A | |
| SCHEMBL9968445 | 0.82 | SMO (0.52) | SMOKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL9932531 | 0.81 | MEN1 (0.43) | SMOKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL9968459 | 0.80 | MEN1 (0.42) | SMOPTPN11KMT2AKDM4ENPC1 | |
| SCHEMBL9933199 | 0.80 | PTPN11 (0.44) | SMOPTPN11MAPTKMT2AKDM4E | |
| SCHEMBL9968340 | 0.80 | MEN1 (0.40) | SMOPTPN11MAPTKMT2AKDM4E | |
| SCHEMBL9933504 | 0.79 | KDM4E (0.41) | SMOKMT2AKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2011027249-A2 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | SMO 1/4885PTPN11 3299/4885CDK8 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.