Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9932010 | 0.87 | BRAF (0.41) | BRAFKDRLCK | |
| SCHEMBL9932667 | 0.83 | JAK1 (0.40) | BRAF | |
| SCHEMBL9967956 | 0.78 | BRAF (0.66) | BRAF | |
| SCHEMBL9932544 | 0.78 | BRAF (0.39) | BRAFPARP1RPS6KB1KDR | |
| SCHEMBL11971840 | 0.74 | BRAF (0.44) | BRAFRPS6KB1LCK | |
| SCHEMBL9932669 | 0.70 | BRAF (0.43) | BRAF | |
| SCHEMBL8293815 | 0.69 | LCK (0.45) | BRAFLCK | |
| SCHEMBL28894969 | 0.67 | PTK2 (0.44) | RPS6KB1KDR | |
| SCHEMBL2623135 | 0.66 | KDM4E (0.39) | — | |
| SCHEMBL17372625 | 0.65 | TARS1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157453-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157453-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | BRAF 1/4885PARP1 2993/4885RPS6KB1 410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.