Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 12/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 8/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.54 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9933214 | 0.85 | CSNK1D (0.60) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9933228 | 0.84 | CSNK1D (0.55) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9933429 | 0.82 | CSNK1D (0.60) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9933162 | 0.80 | CSNK1D (0.61) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9933209 | 0.78 | CSNK1D (0.59) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9933636 | 0.77 | CSNK1D (0.57) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9932617 | 0.77 | CSNK1D (0.66) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9932158 | 0.77 | CSNK1D (0.69) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9932821 | 0.76 | CSNK1D (0.80) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 | |
| SCHEMBL9933235 | 0.75 | CSNK1D (0.52) | CSNK1DCSNK1EMAPK14MAP4K4MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181133-A1 | NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS | Pfizer Inc (US) | 2017-06-21 | — | — | EP | disclosed |
| EP-2654750-A1 | NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS | Pfizer Inc (US) | 2013-10-30 | — | — | EP | disclosed |
| US-8536164-B2 | Fused pyridine compounds as casein kinase inhibitors | PFIZER INC. (US) | 2013-09-17 | — | — | US | disclosed |
| WO-2012085721-A1 | NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS | PFIZER INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| US-20120157440-A1 | NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS | PFIZER INC | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157440-A1 | NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS | CSNK1A1, CSNK1A1L, CSNK1E | CSNK1D 10/4885CSNK1E 3/4885MAPK14 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.