SCHEMBL9935751

SCHEMBL9935751

CC(NC(=O)CBr)c1nc2c(N3CCOCC3)nc(Cl)nc2[nH]1

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.35
PRCP P42785 3/20 0.34
TDP1 Q9NUW8 2/20 0.34
P2RX3 P56373 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
NT5E P21589 1/20 0.32
HDAC2 Q92769 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10008467 0.81 SMN1; SMN2 (0.38) HDAC1SMN1; SMN2ALDH1A1
SCHEMBL30670395 0.79 SLC29A1 (0.40) HDAC1P2RX3SMN1; SMN2NT5E
SCHEMBL9936755 0.78 SMN1; SMN2 (0.37) HDAC1SMN1; SMN2
SCHEMBL9935756 0.76 ADORA1 (0.37) HDAC1P2RX3NT5EHDAC2
SCHEMBL9937094 0.73 HDAC1 (0.41) HDAC1SMN1; SMN2ALDH1A1
SCHEMBL19946533 0.73 HDAC1 (0.38) HDAC1P2RX3SMN1; SMN2NT5EALDH1A1
SCHEMBL18123334 0.73 POLB (0.38) HDAC1P2RX3SMN1; SMN2ALDH1A1
SCHEMBL9937339 0.73 SMN1; SMN2 (0.34) HDAC1P2RX3SMN1; SMN2
SCHEMBL30076404 0.73 SMN1; SMN2 (0.34) HDAC1P2RX3SMN1; SMN2
SCHEMBL20922035 0.72 HDAC1 (0.36) HDAC1P2RX3SMN1; SMN2NT5EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388599-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2025-12-25 US disclosed
US-20220348593-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH, INC. 2022-11-03 US disclosed
US-20190330235-A1 TRICYCLIC P13K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2019-10-31 US disclosed
US-20190330235-A1 TRICYCLIC P13K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2019-10-31 US disclosed
US-20170233407-A1 TRICYCLIC P13K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2017-08-17 US disclosed
US-20170233407-A1 TRICYCLIC P13K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2017-08-17 US disclosed
US-9546182-B2 Tricyclic PI3K inhibitor compounds and methods of use GENENTECH, INC. 2017-01-17 US disclosed
US-9546182-B2 Tricyclic PI3K inhibitor compounds and methods of use GENENTECH, INC. 2017-01-17 US disclosed
EP-3053925-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE F. Hoffmann-La Roche AG (CH) 2016-08-10 EP disclosed
EP-3053925-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE F. Hoffmann-La Roche AG (CH) 2016-08-10 EP disclosed
EP-2813506-A1 Tricyclic PI3K inhibitor compounds and methods of use F. Hoffmann-La Roche AG (CH) 2014-12-17 EP disclosed
EP-2813506-A1 Tricyclic PI3K inhibitor compounds and methods of use F. Hoffmann-La Roche AG (CH) 2014-12-17 EP disclosed
EP-2651951-B1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE HOFFMANN LA ROCHE (CH) 2014-11-19 EP disclosed
EP-2651951-B1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE HOFFMANN LA ROCHE (CH) 2014-11-19 EP disclosed
US-8883799-B2 Tricyclic PI3K inhibitor compounds and methods of use GENENTECH, INC. (US) 2014-11-11 US disclosed
US-8883799-B2 Tricyclic PI3K inhibitor compounds and methods of use GENENTECH, INC. (US) 2014-11-11 US disclosed
EP-2651951-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE F.HOFFMANN-LA ROCHE AG (CH) 2013-10-23 EP disclosed
US-20120171199-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE NOVOGEN LIMITED (AU) 2012-07-05 US disclosed
US-20120171199-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE NOVOGEN LIMITED (AU) 2012-07-05 US disclosed
WO-2012082997-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE F. HOFFMANN-LA-ROCHE AG (CH) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190330235-A1 TRICYCLIC P13K INHIBITOR COMPOUNDS AND METHODS OF USE PI4KB, PI4KA, PIK3CA HDAC1 445/4885PRCP 2657/4885TDP1 718/4885
US-20120171199-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE PIK3CA, PIK3CD, MTOR HDAC1 298/4885PRCP 3087/4885TDP1 1257/4885
US-20170233407-A1 TRICYCLIC P13K INHIBITOR COMPOUNDS AND METHODS OF USE PI4KB, PI4KA, PIK3CA HDAC1 445/4885PRCP 2657/4885TDP1 718/4885
US-20220348593-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE PIK3CA, PIK3CD, MTOR HDAC1 298/4885PRCP 3087/4885TDP1 1257/4885
US-20250388599-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE PIK3C2B, PIK3C2A, PIK3R1 HDAC1 277/4885PRCP 3501/4885TDP1 2491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.