Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.51 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | STK16 | O75716 | 1/20 | 0.51 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL993387 | 0.88 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL13640222 | 0.88 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL3621445 | 0.88 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL3624204 | 0.86 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL994909 | 0.86 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2464786 | 0.86 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL995625 | 0.85 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL2463224 | 0.85 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL2465908 | 0.85 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL2465442 | 0.83 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293735-B2 | Thienopyrimidine derivatives as P13K inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-23 | — | — | US | claimed |
| US-20110021496-A1 | THIENOPYRIMIDINE DERIVATIVES AS P13K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-27 | — | — | US | claimed |
| EP-2205610-B1 | THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-11-20 | — | — | EP | disclosed |
| US-8293735-B2 | Thienopyrimidine derivatives as P13K inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-23 | — | — | US | disclosed |
| US-20110021496-A1 | THIENOPYRIMIDINE DERIVATIVES AS P13K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-27 | — | — | US | disclosed |
| EP-2205610-A1 | THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009053715-A1 | THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021496-A1 | THIENOPYRIMIDINE DERIVATIVES AS P13K INHIBITORS | PIK3CA, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CA 1/4885PIK3CB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.