Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.51 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.45 |
| ▸ | NNMT | P40261 | 9/20 | 0.43 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.42 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.42 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.42 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.42 |
| ▸ | AMD1 | P17707 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9936317 | 0.92 | PI4KA (0.51) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL9936808 | 0.91 | PI4KA (0.53) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL9937444 | 0.85 | PI4KA (0.49) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL9940998 | 0.84 | DOT1L (0.62) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL15395442 | 0.84 | DOT1L (0.62) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL9937533 | 0.83 | PI4KA (0.53) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL17773141 | 0.81 | PI4KA (0.65) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL15395746 | 0.81 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL9970658 | 0.80 | PI4KA (0.61) | PI4KAPI4K2BPI4K2API4KBDOT1L | |
| SCHEMBL15395697 | 0.80 | PI4KA (0.61) | PI4KAPI4K2BPI4K2API4KBDOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646455-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |