Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.37 |
| ▸ | AURKA | O14965 | 11/20 | 0.37 |
| ▸ | PLK1 | P53350 | 10/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.37 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND3 | P30281 | 2/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9937727 | 0.90 | CDK2 (0.44) | CDK2CCNA2CCNA1AURKAPLK1 | |
| Trifluoroacetic Acid SCHEMBL9937516 | 0.85 | CDK2 (0.44) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL9940817 | 0.84 | CDK2 (0.52) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL9940634 | 0.74 | CDK2 (0.63) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL9937702 | 0.73 | HDAC6 (0.36) | TTK | |
| SCHEMBL11938648 | 0.72 | CCNA2 (0.57) | CDK2CCNA2CCNA1AURKAPLK1 | |
| Hydrochloric Acid SCHEMBL1655408 | 0.72 | CDK2 (0.47) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL11026206 | 0.70 | CDK2 (0.54) | CDK2CCNA2CCNA1AURKAPLK1 | |
| Trifluoroacetic Acid SCHEMBL9940859 | 0.70 | CDK2 (0.61) | CDK2CCNA2CCNA1AURKAPLK1 | |
| Hydrochloric Acid SCHEMBL6793621 | 0.69 | MAPKAPK2 (0.43) | CDK2CCNA2CCNA1AURKAPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614065-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012080990-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-21 | — | — | WO | disclosed |