Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.65 |
| ▸ | EMG1 | Q92979 | 2/20 | 0.65 |
| ▸ | MME | P08473 | 18/20 | 0.62 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930147 | 1.00 | ACE (0.65) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9930001 | 0.92 | ACE (0.64) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9929898 | 0.92 | ACE (0.67) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9938846 | 0.90 | ACE (0.76) | ACEEMG1MME | |
| SCHEMBL9930493 | 0.90 | ACE (0.76) | ACEEMG1MME | |
| SCHEMBL17011164 | 0.90 | ACE (0.65) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9929821 | 0.89 | ACE (0.51) | ACEEMG1MMEMMEL1 | |
| SCHEMBL17011163 | 0.89 | ACE (0.75) | ACEEMG1MME | |
| SCHEMBL23420472 | 0.89 | ACE (0.62) | ACEEMG1MMEMMEL1 | |
| SCHEMBL17011168 | 0.89 | ACE (0.62) | ACEEMG1MMEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651896-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |