Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 6/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | AMD1 | P17707 | 3/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | PCMT1 | P22061 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9937234 | 0.87 | DOT1L (0.56) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9937221 | 0.86 | PI4KA (0.54) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9936482 | 0.86 | PI4KA (0.54) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9937219 | 0.86 | DOT1L (0.54) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9937222 | 0.86 | PI4KA (0.53) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9937118 | 0.85 | PI4KA (0.55) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9937547 | 0.84 | PI4KA (0.51) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970300 | 0.83 | DOT1L (0.61) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9940551 | 0.83 | DOT1L (0.61) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9940552 | 0.83 | DOT1L (0.61) | PI4KAPI4K2BPI4K2API4KBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646455-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |