Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14245217 | 1.00 | ABL1 (0.72) | ABL1 | |
| SCHEMBL9938850 | 0.84 | ABL1 (1.00) | ABL1 | |
| SCHEMBL14244774 | 0.81 | ABL1 (0.60) | ABL1 | |
| SCHEMBL30907207 | 0.81 | ABL1 (0.60) | ABL1 | |
| SCHEMBL24897701 | 0.80 | TYK2 (0.56) | ABL1 | |
| SCHEMBL22659833 | 0.80 | TYK2 (0.56) | ABL1 | |
| SCHEMBL22659834 | 0.80 | TYK2 (0.56) | ABL1 | |
| SCHEMBL20516798 | 0.79 | MAP4K1 (0.57) | — | |
| SCHEMBL20517171 | 0.79 | MAP4K1 (0.57) | — | |
| SCHEMBL23429290 | 0.79 | MAP4K1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651899-A2 | SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF | F.HOFFMANN-LA ROCHE AG (CH) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012080284-A2 | SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-21 | — | — | WO | disclosed |