Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1150913 | 1.00 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL21874256 | 1.00 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL11450804 | 1.00 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL2499400 | 1.00 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL1334730 | 0.91 | POLB (0.47) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL1335928 | 0.91 | POLB (0.47) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL1335516 | 0.91 | POLB (0.47) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL1335517 | 0.91 | POLB (0.47) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL1335456 | 0.91 | POLB (0.47) | NPC1RAB9ASMN1; SMN2POLBPSEN1 | |
| SCHEMBL19540632 | 0.91 | POLB (0.49) | NPC1RAB9ASMN1; SMN2POLBPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430035-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 Pharma LLC (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086383-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2023-05-19 | — | — | WO | disclosed |
| US-8203003-B2 | 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods | UBE INDUSTRIES, LTD. (JP) | 2012-06-19 | — | — | US | disclosed |