Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 15/20 | 0.52 |
| ▸ | LMNA | P02545 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435026 | 0.80 | MEN1 (0.62) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL19936511 | 0.79 | SMN1; SMN2 (0.62) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL11725268 | 0.77 | POLB (0.57) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL829880 | 0.77 | MEN1 (0.62) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL1426313 | 0.77 | MEN1 (0.62) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL25001244 | 0.75 | TP53 (0.60) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL29722013 | 0.75 | SMN1; SMN2 (0.60) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL3021566 | 0.75 | SMN1; SMN2 (0.60) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL3435382 | 0.75 | MEN1 (0.59) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL3437821 | 0.73 | MEN1 (0.58) | MEN1KMT2ATP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646455-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |