Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 14/20 | 0.46 |
| ▸ | CDK2 | P24941 | 14/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.46 |
| ▸ | AURKA | O14965 | 9/20 | 0.46 |
| ▸ | PLK1 | P53350 | 8/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.43 |
| ▸ | TTK | P33981 | 3/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.40 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CCND3 | P30281 | 3/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941078 | 0.90 | CCNA2 (0.52) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL9941063 | 0.88 | CDK2 (0.46) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL9941217 | 0.86 | CDK2 (0.48) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL17746006 | 0.80 | CCNA2 (0.52) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL9940625 | 0.80 | CCNA2 (0.53) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL9940604 | 0.75 | CDK2 (0.48) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL17746013 | 0.72 | CDK2 (0.60) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL17745986 | 0.72 | PLK1 (0.49) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL3503141 | 0.72 | CDK2 (0.52) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL17746016 | 0.72 | CCNA2 (0.54) | CCNA2CDK2CCNA1AURKAPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614065-B1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2017-04-19 | — | — | EP | disclosed |
| US-8541576-B2 | Substituted pyrazolo-quinazoline derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-09-24 | — | — | US | disclosed |
| EP-2614065-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2013-07-17 | — | — | EP | disclosed |
| US-20120190678-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2012-07-26 | — | — | US | disclosed |
| WO-2012080990-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190678-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | PIM1, PIM2, PIM3 | CCNA2 1765/4885CDK2 113/4885CCNA1 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.