Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 16/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941106 | 0.93 | TTK (0.45) | TTKFLT3 | |
| SCHEMBL9941400 | 0.91 | TTK (0.54) | TTKKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9941206 | 0.88 | TTK (0.42) | TTK | |
| SCHEMBL9941002 | 0.86 | TTK (0.47) | TTK | |
| SCHEMBL9940878 | 0.84 | TTK (0.46) | TTK | |
| SCHEMBL9941150 | 0.84 | FLT3 (0.43) | TTKFLT3 | |
| SCHEMBL9941057 | 0.84 | TTK (0.53) | TTKFLT3 | |
| SCHEMBL9941302 | 0.84 | TTK (0.43) | TTKKDM4EALDH1A1 | |
| SCHEMBL9940932 | 0.83 | TTK (0.39) | TTKKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9941040 | 0.83 | TTK (0.41) | TTKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651948-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | Bayer Intellectual Property GmbH (DE) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080229-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-21 | — | — | WO | claimed |