Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.51 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930079 | 1.00 | MME (0.51) | MMEMMEL1ACE | |
| SCHEMBL9940911 | 0.93 | MME (0.51) | MMEACE | |
| SCHEMBL9930092 | 0.93 | MME (0.51) | MMEACE | |
| SCHEMBL9929620 | 0.93 | MME (0.59) | MMEMMEL1 | |
| SCHEMBL9940924 | 0.93 | MME (0.59) | MMEMMEL1 | |
| SCHEMBL9929751 | 0.92 | MME (0.53) | MMEMMEL1ACE | |
| SCHEMBL9941348 | 0.91 | MME (0.53) | MMEMMEL1ACE | |
| SCHEMBL9929753 | 0.91 | MME (0.53) | MMEMMEL1ACE | |
| SCHEMBL9930310 | 0.91 | MME (0.53) | MMEMMEL1ACE | |
| SCHEMBL9930102 | 0.90 | MME (0.57) | MMEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651896-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |