Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.39 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.39 |
| ▸ | MME | P08473 | 9/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929680 | 1.00 | FOLH1 (0.42) | FOLH1SRRPSAT1MMECHRM1 | |
| SCHEMBL14890861 | 0.90 | MME (0.47) | MMEACE | |
| SCHEMBL19190551 | 0.90 | MME (0.47) | MMEACE | |
| SCHEMBL18724735 | 0.82 | MME (0.46) | MMEACE | |
| SCHEMBL17011152 | 0.82 | MME (0.46) | MMEACE | |
| SCHEMBL9929533 | 0.81 | MME (0.53) | SRRPSAT1MMEGPR88ACE | |
| SCHEMBL9966297 | 0.81 | MME (0.53) | SRRPSAT1MMEGPR88ACE | |
| SCHEMBL9929512 | 0.81 | MME (0.53) | SRRPSAT1MMEGPR88ACE | |
| SCHEMBL9929510 | 0.81 | MME (0.53) | SRRPSAT1MMEGPR88ACE | |
| SCHEMBL9929634 | 0.81 | MME (0.53) | SRRPSAT1MMEGPR88ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651896-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |