Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941388 | 0.82 | KDM4E (0.30) | CCR1CCR5CCR8 | |
| SCHEMBL15903546 | 0.68 | — | — | |
| SCHEMBL29564692 | 0.68 | — | — | |
| SCHEMBL15903796 | 0.67 | — | — | |
| SCHEMBL14941252 | 0.61 | — | — | |
| SCHEMBL29447186 | 0.61 | — | — | |
| SCHEMBL18849413 | 0.59 | CCR1 (0.50) | CCR1CCR5CCR8HDAC6 | |
| SCHEMBL22224024 | 0.58 | CCR1 (0.48) | CCR1CCR5CCR8HDAC6 | |
| SCHEMBL9616686 | 0.58 | CCR1 (0.48) | CCR1CCR5CCR8HDAC6 | |
| SCHEMBL25860933 | 0.57 | CCR1 (0.47) | CCR1CCR5CCR8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651916-A2 | C-17-HETEROARYL STEROIDAL COMPOUNDS AS INHIBITORS OF CYP11B, CYP17, AND/OR CYP21 | BioMarin Pharmaceutical Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012083112-A2 | CYP11B, CYP17, AND/OR CYP21 INHIBITORS | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-06-21 | — | — | WO | disclosed |