Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | PLK1 | P53350 | 10/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.39 |
| ▸ | AURKA | O14965 | 6/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.35 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940634 | 0.83 | CDK2 (0.63) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL9940859 | 0.79 | CDK2 (0.61) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| SCHEMBL9940894 | 0.77 | CDK2 (0.67) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| Hydrochloric Acid SCHEMBL11028836 | 0.76 | CDK2 (0.66) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| SCHEMBL9940817 | 0.74 | CDK2 (0.52) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| SCHEMBL18751495 | 0.74 | CDK2 (0.60) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL9940945 | 0.74 | CDK2 (0.53) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| SCHEMBL11026206 | 0.73 | CDK2 (0.54) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| SCHEMBL9940946 | 0.72 | CDK2 (0.49) | CDK2PDPK1PLK1CCNA2CCNA1 | |
| SCHEMBL9940382 | 0.70 | CDK2 (0.67) | CDK2PDPK1PLK1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614065-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012080990-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-21 | — | — | WO | disclosed |