Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15446264 | 1.00 | PIM1 (0.39) | PIM1PIM2USP30BRD4KMT2A | |
| SCHEMBL9904379 | 1.00 | PIM1 (0.39) | PIM1PIM2USP30BRD4KMT2A | |
| SCHEMBL9904239 | 0.80 | PIM1 (0.43) | PIM1PIM2USP30KMT2APARP1 | |
| SCHEMBL9904437 | 0.80 | CKS1B (0.37) | PIM1PIM2KMT2ATRPV1MEN1 | |
| SCHEMBL9904528 | 0.79 | PIK3CD (0.39) | PIM1PIM2USP30BRD4PARP1 | |
| SCHEMBL9904525 | 0.79 | PIK3CD (0.39) | PIM1PIM2USP30BRD4PARP1 | |
| SCHEMBL9904146 | 0.78 | PIM1 (0.41) | PIM1PIM2USP30BRD4PARP1 | |
| SCHEMBL9904144 | 0.78 | PIM1 (0.41) | PIM1PIM2USP30BRD4PARP1 | |
| SCHEMBL9901269 | 0.76 | TYK2 (0.42) | PIM1PIM2HTR6BCHEGPR119 | |
| SCHEMBL9901268 | 0.76 | TYK2 (0.42) | PIM1PIM2HTR6BCHEGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |