Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | DOT1L | Q8TEK3 | 8/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | AMD1 | P17707 | 2/20 | 0.43 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970654 | 1.00 | RXFP1 (0.49) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9942361 | 1.00 | RXFP1 (0.49) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9942362 | 1.00 | RXFP1 (0.49) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9940637 | 0.88 | DOT1L (0.58) | DOT1LFASN | |
| SCHEMBL9970201 | 0.88 | DOT1L (0.58) | DOT1LFASN | |
| SCHEMBL9940505 | 0.87 | DOT1L (0.49) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970200 | 0.87 | PI4KA (0.50) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9940969 | 0.87 | PI4KA (0.50) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9940967 | 0.87 | PI4KA (0.50) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9940737 | 0.86 | DOT1L (0.59) | DOT1LFASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646455-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |