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SCHEMBL9942843

SCHEMBL9942843

CCCC(O)c1cc2c(=O)n(NSC)c(=O)[nH]c2cc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ DDR1 Q08345 2/20 0.40
▸ CA12 O43570 3/20 0.36
▸ CA9 Q16790 3/20 0.36
▸ AR P10275 10/20 0.34
▸ NR3C1 P04150 1/20 0.31
▸ PGR P06401 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9942847 0.86 CA12 (0.40) DDR1CA12CA9AR
SCHEMBL961236 0.84 DDR1 (0.43) DDR1CA12CA9AR
SCHEMBL9942831 0.84 CA12 (0.38) DDR1CA12CA9AR
SCHEMBL9942861 0.82 AR (0.37) DDR1CA12CA9AR
SCHEMBL14773371 0.81 AR (0.34) DDR1CA12CA9AR
SCHEMBL9942836 0.80 AR (0.36) DDR1CA12CA9AR
SCHEMBL9942840 0.79 CA12 (0.38) CA12CA9AR
SCHEMBL9942848 0.79 CA12 (0.35) DDR1CA12CA9AR
SCHEMBL9942853 0.78 AR (0.35) DDR1CA12CA9AR
SCHEMBL1660964 0.76 DDR1 (0.45) DDR1CA12CA9AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2476671-A1 1H-Quinazoline-2,4-diones Novartis AG (CH) 2012-07-18 — — EP disclosed
EP-2468732-A1 1H-Quinazoline-2,4-diones Novartis AG (CH) 2012-06-27 — — EP disclosed
EP-2463278-A1 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS Novartis AG (CH) 2012-06-13 — — EP disclosed