Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9942859 | 0.89 | PDE3B (0.38) | ARCA12CA9PDE3BPDE3A | |
| SCHEMBL2390931 | 0.87 | HAVCR2 (0.40) | HAVCR2CA12CA9PDE3BPDE3A | |
| SCHEMBL2387497 | 0.87 | DDR1 (0.40) | HAVCR2ARKIF11 | |
| SCHEMBL2388699 | 0.83 | PARP1 (0.44) | ARCA12CA9 | |
| SCHEMBL2390366 | 0.83 | CA12 (0.36) | HAVCR2CA12CA9 | |
| SCHEMBL2389629 | 0.82 | CA12 (0.39) | HAVCR2CA12CA9 | |
| SCHEMBL2390743 | 0.82 | BRD4 (0.36) | CA12CA9 | |
| SCHEMBL2389449 | 0.82 | CFTR (0.43) | CA12CA9PDE3BPDE3APTGS2 | |
| SCHEMBL2389240 | 0.81 | PIK3CA (0.41) | PTGS2 | |
| Hydrochloric Acid SCHEMBL2390612 | 0.81 | BRD4 (0.36) | CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476671-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| EP-2468732-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| EP-2463278-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (CH) | 2012-06-13 | — | — | EP | disclosed |