Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD1 | O95696 | 1/20 | 0.41 |
| ▸ | CCL2 | P13500 | 1/20 | 0.41 |
| ▸ | TAF1 | P21675 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2419533 | 0.83 | MAPK14 (0.48) | MAPK13MAPK14CYP2C9TRIM24BRD4 | |
| SCHEMBL2418823 | 0.73 | MAPK14 (0.53) | MAPK13MAPK14CYP2C9TRIM24BRD4 | |
| SCHEMBL2420323 | 0.71 | MAPK14 (0.59) | MAPK14CYP2C9 | |
| SCHEMBL2421708 | 0.69 | MAPK14 (0.61) | MAPK14CYP2C9TRIM24BRD4BRD1 | |
| SCHEMBL14269520 | 0.69 | MAPK14 (0.62) | MAPK13MAPK14CYP2C9 | |
| SCHEMBL20448732 | 0.68 | MAPK14 (0.77) | MAPK13MAPK14CYP2C9 | |
| SCHEMBL2422941 | 0.68 | MAPK14 (0.56) | MAPK13EGLN1MAPK14CYP2C9TRIM24 | |
| SCHEMBL2414058 | 0.67 | MAPK14 (0.53) | MAPK14TRIM24BRD4BRD1CCL2 | |
| SCHEMBL2420062 | 0.67 | MAPK14 (0.47) | MAPK13MAPK14CYP2C9 | |
| SCHEMBL2398090 | 0.66 | MAPK14 (0.46) | MAPK13MAPK14CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144881-B1 | ISOQUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( COPD ) AND ASTHMA | ASTRAZENECA AB (SE) | 2012-06-20 | — | — | EP | disclosed |