Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 15/20 | 0.82 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.59 |
| ▸ | KDM5A | P29375 | 1/20 | 0.59 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729153 | 0.99 | DHODH (0.80) | DHODHKDM4CKDM5AKDM5BCSNK2A2 | |
| SCHEMBL3736385 | 0.91 | DHODH (0.80) | DHODHKDM4CKDM5AKDM5B | |
| Lithium Ion SCHEMBL729152 | 0.90 | DHODH (1.00) | DHODHKDM4CKDM5AKDM5BCSNK2A2 | |
| SCHEMBL9943607 | 0.88 | DHODH (0.65) | DHODH | |
| SCHEMBL729531 | 0.87 | DHODH (0.64) | DHODH | |
| SCHEMBL9943553 | 0.85 | DHODH (0.82) | DHODHKDM4C | |
| SCHEMBL727801 | 0.84 | DHODH (0.61) | DHODHKDM4C | |
| SCHEMBL727804 | 0.84 | DHODH (0.81) | DHODHKDM4C | |
| SCHEMBL18109142 | 0.84 | DHODH (0.72) | DHODHIGF2BP2 | |
| SCHEMBL9943542 | 0.83 | DHODH (0.83) | DHODHKDM4CKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121614-B1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | ALMIRALL SA (ES) | 2012-06-20 | — | — | EP | claimed |
| US-8258308-B2 | Amino nicotinic and isonicotinic acid derivatives as DHODH inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2012-09-04 | — | — | US | disclosed |
| US-20100074898-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100074898-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | DHODH, NQO2, DAO | DHODH 1/4885KDM4C 3252/4885KDM5A 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.