Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 7/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ATF4 | P18848 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729430 | 0.86 | KCNJ1 (0.65) | KCNJ1POLBBLMTDP1KMT2A | |
| SCHEMBL21460046 | 0.76 | MAPT (0.58) | KCNJ1POLBBLMTDP1KMT2A | |
| SCHEMBL14921306 | 0.74 | KCNJ1 (0.74) | KCNJ1LMNAALDH1A1 | |
| SCHEMBL20357770 | 0.73 | KCNJ1 (0.56) | KCNJ1POLBBLMTDP1 | |
| SCHEMBL16897509 | 0.73 | KCNJ1 (1.00) | KCNJ1TDP1KMT2ALMNAALDH1A1 | |
| SCHEMBL14919593 | 0.72 | KCNJ1 (0.71) | KCNJ1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL28284732 | 0.72 | UBE2T (0.53) | POLBKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL29177328 | 0.72 | UBE2T (0.49) | POLBKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL1164007 | 0.72 | KCNJ1 (0.58) | KCNJ1POLBBLMTDP1MAPT | |
| SCHEMBL14069481 | 0.72 | KCNJ1 (0.58) | KCNJ1MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2790511-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013090271-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-06-20 | — | — | WO | disclosed |
| EP-2464228-A1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck Sharp & Dohme Corp. (US) | 2012-06-20 | — | — | EP | disclosed |