Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 9/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.49 |
| ▸ | FLT1 | P17948 | 6/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9944048 | 0.97 | PDPK1 (0.52) | PDPK1FGFR1FLT1ABL1CHEK1 | |
| SCHEMBL1225651 | 0.77 | PDPK1 (0.50) | PDPK1FGFR1FLT1CHEK1WNT1 | |
| SCHEMBL9944050 | 0.77 | PDPK1 (0.50) | PDPK1FGFR1FLT1CHEK1WNT1 | |
| SCHEMBL12885898 | 0.73 | CCNC (0.55) | PDPK1CHEK1FLT3 | |
| SCHEMBL4432759 | 0.73 | PDPK1 (0.67) | PDPK1FGFR1FLT1ABL1CHEK1 | |
| SCHEMBL1224541 | 0.72 | FLT3 (0.61) | PDPK1FGFR1FLT1CHEK1FLT3 | |
| SCHEMBL1224994 | 0.71 | FLT3 (0.60) | PDPK1FGFR1FLT1CHEK1FLT3 | |
| SCHEMBL12885878 | 0.71 | FLT3 (0.61) | PDPK1CHEK1FLT3 | |
| SCHEMBL3533024 | 0.70 | PDPK1 (0.73) | PDPK1FGFR1FLT1ABL1CHEK1 | |
| SCHEMBL12885890 | 0.69 | PDPK1 (0.50) | PDPK1FGFR1FLT1CHEK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464231-A1 | INDAZOLES AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC USES THEREOF | Epitherix, LLC (US) | 2012-06-20 | — | — | EP | disclosed |