Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.66 |
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734516 | 0.86 | APP (0.64) | APPMAOBESR1ESR2L3MBTL1 | |
| SCHEMBL11850978 | 0.83 | MAOB (0.80) | APPMAOBESR1ESR2TNKS | |
| SCHEMBL7117044 | 0.82 | MAOB (0.69) | APPMAOBESR1ESR2ADORA3 | |
| SCHEMBL15080535 | 0.81 | APP (0.57) | APPMAOBL3MBTL1APAF1USP2 | |
| SCHEMBL14076003 | 0.79 | APP (0.68) | APPMAOBESR1ESR2L3MBTL1 | |
| SCHEMBL17427775 | 0.79 | MAOB (0.62) | MAOBESR1ESR2TNKSADORA3 | |
| SCHEMBL21860421 | 0.77 | MAOB (0.74) | APPMAOBESR1ESR2TNKS | |
| SCHEMBL12422881 | 0.77 | MAOB (0.54) | APPMAOBESR1ESR2ALDH1A1 | |
| SCHEMBL11851368 | 0.77 | MAOB (0.61) | APPMAOBESR1ESR2TNKS | |
| SCHEMBL9133017 | 0.77 | APP (0.65) | APPMAOBL3MBTL1APAF1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120148494-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-06-14 | — | — | US | disclosed |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | UNIVERSITY OF PITTSBURGH- OF COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120148494-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | BACE1, APP, BACE2 | APP 2/4885MAOB 1812/4885ESR1 2586/4885 |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | BACE1, APP, BACE2 | APP 2/4885MAOB 1693/4885ESR1 2826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.