Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 17/20 | 0.45 |
| ▸ | JAK1 | P23458 | 11/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6126483 | 0.93 | TYRO3 (0.57) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL9947527 | 0.91 | TYRO3 (0.48) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL8586705 | 0.91 | TYRO3 (0.48) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL9947529 | 0.90 | TYRO3 (0.47) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL8553608 | 0.90 | TYRO3 (0.47) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL9947530 | 0.90 | TYRO3 (0.48) | TYRO3AXLMERTKJAK2JAK1 | |
| Trifluoroacetic Acid SCHEMBL6126211 | 0.90 | TYRO3 (0.54) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL8554665 | 0.90 | TYRO3 (0.53) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL9947520 | 0.90 | TYRO3 (0.48) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL9947531 | 0.89 | TYRO3 (0.52) | TYRO3AXLMERTKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149682-A1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | INCYTE CORPORATION | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149682-A1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | JAK2, JAK1, JAK3 | TYRO3 74/4885AXL 355/4885MERTK 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.