Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 17/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947908 | 1.00 | PTGER4 (0.48) | PTGER4CYP1A2CYP2D6FABP5MEN1 | |
| SCHEMBL8514147 | 0.96 | PTGER4 (0.51) | PTGER4CYP1A2CYP2D6FABP5MEN1 | |
| SCHEMBL1591394 | 0.96 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6MEN1CYP2C9 | |
| SCHEMBL10058512 | 0.96 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6MEN1CYP2C9 | |
| SCHEMBL4610970 | 0.91 | PTGER4 (0.60) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9947661 | 0.91 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL10058570 | 0.90 | PTGER4 (0.42) | PTGER4CYP1A2CYP2D6MEN1CYP2C9 | |
| SCHEMBL10058571 | 0.90 | PTGER4 (0.42) | PTGER4CYP1A2CYP2D6MEN1CYP2C9 | |
| SCHEMBL9947864 | 0.89 | PTGER4 (0.50) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9948203 | 0.89 | PTGER4 (0.52) | PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979317-B1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LTD (GB) | 2012-08-22 | — | — | EP | disclosed |
| US-8207213-B2 | Benzoisoindole derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |