Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947569 | 1.00 | BACE1 (0.59) | BACE1 | |
| Hydrochloric Acid SCHEMBL14300772 | 0.99 | BACE1 (0.58) | BACE1 | |
| SCHEMBL936349 | 0.88 | BACE1 (0.62) | BACE1 | |
| SCHEMBL936350 | 0.88 | BACE1 (0.62) | BACE1 | |
| SCHEMBL8513433 | 0.88 | BACE1 (0.62) | BACE1 | |
| Hydrochloric Acid SCHEMBL9947726 | 0.87 | BACE1 (0.64) | BACE1 | |
| Hydrochloric Acid SCHEMBL8516284 | 0.87 | BACE1 (0.64) | BACE1 | |
| Hydrochloric Acid SCHEMBL9947725 | 0.87 | BACE1 (0.64) | BACE1 | |
| Hydrochloric Acid SCHEMBL10006939 | 0.86 | BACE1 (0.63) | BACE1 | |
| SCHEMBL9947575 | 0.84 | BACE1 (0.56) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456763-B1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2015-01-21 | — | — | EP | claimed |
| US-8207164-B2 | Oxazine derivatives and their use in the treatment of neurological disorders | NOVARTIS AG (CH) | 2012-06-26 | — | — | US | disclosed |