Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 7/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.66 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 4/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.59 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | AXL | P30530 | 1/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410435 | 0.91 | MAPK13 (0.78) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL1410701 | 0.91 | MAPK13 (0.78) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL1410442 | 0.90 | MAPK13 (0.72) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL1410646 | 0.90 | MAPK13 (0.79) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL2253982 | 0.89 | MAPK13 (0.75) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL1410341 | 0.89 | MAPK13 (0.78) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL1409760 | 0.87 | MAPK13 (0.75) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL3472215 | 0.86 | MAPK13 (0.77) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL1410016 | 0.86 | MAPK13 (0.71) | MAPK13MAPK14RAF1BRAFPTK2 | |
| SCHEMBL1410482 | 0.86 | MAPK13 (0.73) | MAPK13MAPK14RAF1BRAFPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207166-B2 | Substituted pyrazolyl urea derivatives useful in the treatment of cancer | BAYER HEALTHCARE LLC (US) | 2012-06-26 | — | — | US | disclosed |