Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 18/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 18/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1124193 | 0.76 | NR1H2 (0.54) | NR1H2NR1H3PARP1 | |
| SCHEMBL1125252 | 0.74 | NR1H2 (0.46) | NR1H2NR1H3PARP1MEN1TNF | |
| SCHEMBL1124802 | 0.74 | PARP1 (0.45) | NR1H2NR1H3PARP1MEN1TNF | |
| SCHEMBL1125190 | 0.73 | NR1H2 (0.57) | NR1H2NR1H3PARP1 | |
| SCHEMBL995354 | 0.73 | NR1H2 (0.58) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1124728 | 0.73 | NR1H3 (0.50) | NR1H2NR1H3PPARGPPARDPPARA | |
| Hydrochloric Acid SCHEMBL11618873 | 0.72 | NR1H2 (0.56) | NR1H2NR1H3PARP1 | |
| SCHEMBL1124374 | 0.72 | NR1H2 (0.73) | NR1H2NR1H3 | |
| SCHEMBL11201153 | 0.69 | NR1H2 (0.53) | NR1H2NR1H3PARP1 | |
| SCHEMBL11618867 | 0.69 | NR1H2 (0.53) | NR1H2NR1H3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272843-A1 | QUINOLINE COMPOUND | Kowa Company, Ltd. (JP) | 2011-01-12 | — | — | EP | disclosed |