Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.42 |
| ▸ | MTOR | P42345 | 12/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3785586 | 0.95 | PIK3CA (0.41) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3791663 | 0.94 | MTOR (0.46) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| Trifluoroacetic Acid SCHEMBL3790272 | 0.88 | PIK3CA (0.40) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3778314 | 0.87 | MTOR (0.46) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3788818 | 0.85 | MTOR (0.48) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3785227 | 0.83 | MTOR (0.46) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3784601 | 0.83 | PIK3CA (0.42) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3790277 | 0.83 | PIK3CD (0.40) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3785501 | 0.82 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| Trifluoroacetic Acid SCHEMBL3790532 | 0.82 | PIK3CD (0.39) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | MTOR, PIKFYVE, RICTOR | PIK3CA 9/4885MTOR 1/4885PIK3CD 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.