Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amylosulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.87 |
| ▸ | TSHR | P16473 | 2/20 | 0.87 |
| ▸ | GLA | P06280 | 1/20 | 0.87 |
| ▸ | HPGD | P15428 | 1/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.87 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.87 |
| ▸ | BLM | P54132 | 1/20 | 0.87 |
| ▸ | CA1 | P00915 | 12/20 | 0.58 |
| ▸ | CA2 | P00918 | 12/20 | 0.58 |
| ▸ | CA9 | Q16790 | 10/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.56 |
| ▸ | CA7 | P43166 | 3/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.56 |
| ▸ | CA3 | P07451 | 2/20 | 0.56 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
| ▸ | CA6 | P23280 | 2/20 | 0.56 |
| ▸ | CA5A | P35218 | 2/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8371870 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL430295 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL27193 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| Octadecyl Sulfate SCHEMBL29135085 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL18335522 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL3196439 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL6536390 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL10768370 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL10768334 | 0.98 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL1537676 | 0.96 | RECQL (0.96) | RECQLTSHRGLAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165329-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165329-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PRKDC, PRKACA, PRKACG | RECQL 3012/4885TSHR 2257/4885GLA 895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.