Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 17/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 15/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950776 | 0.83 | HCRTR2 (0.41) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL9951026 | 0.83 | HCRTR2 (0.49) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10188722 | 0.80 | HCRTR2 (0.56) | HCRTR2HCRTR1KCNH2ALDH1A1 | |
| SCHEMBL9950438 | 0.78 | HCRTR2 (0.36) | HCRTR2HCRTR1 | |
| SCHEMBL2118887 | 0.76 | HCRTR1 (0.57) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL9950436 | 0.75 | HCRTR2 (0.36) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL9950743 | 0.75 | HCRTR2 (0.55) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10189062 | 0.73 | HCRTR2 (0.70) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10189060 | 0.73 | HCRTR2 (0.71) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL9950717 | 0.72 | HCRTR2 (0.54) | HCRTR2HCRTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | HCRTR2, HCRTR1, CNR1 | HCRTR2 1/4885HCRTR1 2/4885KCNH2 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.