Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 6/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 4/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952996 | 0.87 | STK4 (0.38) | JAK3MAPTMEN1ALDH1A1MAPK1 | |
| SCHEMBL9952040 | 0.86 | CYP1A2 (0.44) | MAPTMEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL21986432 | 0.86 | PIK3CD (0.37) | MAPTMEN1MAPK1KMT2APIK3CD | |
| SCHEMBL9952881 | 0.86 | PIK3CD (0.42) | JAK3MAPTMEN1KMT2APIK3CD | |
| SCHEMBL9953158 | 0.84 | CYP1A2 (0.39) | MAPTMEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL9953762 | 0.83 | CYP1A2 (0.45) | MEN1ALDH1A1MAPK1KMT2APIK3CD | |
| SCHEMBL9952453 | 0.83 | PIK3CD (0.42) | MAPTMEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL9953317 | 0.82 | PTGDR (0.37) | MAPTMEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL9952628 | 0.82 | PIK3CD (0.38) | MAPTMEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL9929383 | 0.82 | PIK3CD (0.51) | JAK3MELKPIK3CDEGFRMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |