Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952961 | 0.85 | PIK3CD (0.45) | PIK3CDPDE5AMAPTTSHRHTT | |
| SCHEMBL9953848 | 0.85 | PIK3CD (0.43) | PIK3CDPDE5AMAPTTSHRHTT | |
| SCHEMBL9953231 | 0.85 | PIK3CD (0.36) | PIK3CDPDE5AMAPTTSHRHTT | |
| SCHEMBL9952295 | 0.83 | PIK3CD (0.38) | PIK3CDPDE5AMAPTTSHRHTT | |
| Trifluoroacetic Acid SCHEMBL9953716 | 0.83 | PIK3CD (0.36) | PIK3CDPDE5A | |
| SCHEMBL9960484 | 0.82 | PIK3CD (0.35) | PIK3CDTSHRHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL9929674 | 0.82 | PIK3CD (0.50) | PIK3CD | |
| Trifluoroacetic Acid SCHEMBL9953150 | 0.80 | PIK3CD (0.33) | PIK3CDPDE5AMAPTTSHRHTT | |
| SCHEMBL9953488 | 0.79 | JAK2 (0.38) | TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL9952126 | 0.78 | PDE5A (0.33) | PDE5AMAPTTSHRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |