Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.74 |
| ▸ | JAK2 | O60674 | 11/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952376 | 1.00 | JAK1 (0.74) | JAK1JAK2JAK3AURKAPRKCA | |
| SCHEMBL12385295 | 0.87 | JAK1 (0.71) | JAK1JAK2JAK3AURKAPRKCA | |
| SCHEMBL2296459 | 0.85 | JAK1 (1.00) | JAK1JAK2JAK3AURKAPRKCA | |
| SCHEMBL2296140 | 0.85 | JAK1 (1.00) | JAK1JAK2JAK3AURKAPRKCA | |
| SCHEMBL2291908 | 0.82 | JAK1 (0.72) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL12385202 | 0.82 | JAK1 (1.00) | JAK1JAK2JAK3AURKAPRKCA | |
| SCHEMBL2286718 | 0.82 | JAK1 (0.91) | JAK1JAK2JAK3AURKAPRKCA | |
| SCHEMBL9953293 | 0.81 | JAK1 (0.56) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL10281503 | 0.79 | JAK1 (0.74) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL9953151 | 0.78 | JAK2 (0.70) | JAK1JAK2JAK3AURKAPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |