Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9929283 | 0.99 | PIK3CD (0.44) | PIK3CDKCNH2AXLMERTKEPHA2 | |
| SCHEMBL9928861 | 0.91 | PIK3CD (0.46) | PIK3CD | |
| SCHEMBL9929375 | 0.90 | PIK3CD (0.56) | PIK3CDAXLMERTK | |
| SCHEMBL9929414 | 0.89 | PIK3CD (0.45) | PIK3CDKCNH2EPHA2KDREPHB4 | |
| Trifluoroacetic Acid SCHEMBL9929120 | 0.84 | PIK3CD (0.51) | PIK3CDAXLMERTK | |
| Trifluoroacetic Acid SCHEMBL9928835 | 0.82 | PIK3CD (0.42) | PIK3CDKCNH2EPHA2KDREPHB4 | |
| SCHEMBL9928691 | 0.82 | PIK3CD (0.47) | PIK3CDKCNH2AXLMERTK | |
| SCHEMBL9928903 | 0.81 | PIK3CD (0.59) | PIK3CDAXLMERTKEPHA2KDR | |
| SCHEMBL9928915 | 0.81 | PIK3CD (0.47) | PIK3CDAXLMERTK | |
| SCHEMBL9928981 | 0.80 | PIK3CD (0.44) | PIK3CDAXLMERTKEPHA2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |