Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14739013 | 0.82 | ELANE (0.36) | ELANEPOLBKDM4EHSD17B10MAPT | |
| SCHEMBL3636090 | 0.81 | ELANE (0.45) | ELANEL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL3518728 | 0.81 | CHEK1 (0.39) | ELANEPOLBKDM4EHSD17B10MEN1 | |
| SCHEMBL9952523 | 0.80 | MAP2K4 (0.42) | ELANEPOLBKDM4EL3MBTL1HSD17B10 | |
| SCHEMBL14631678 | 0.78 | PTGDR2 (0.46) | POLBKDM4EL3MBTL1HSD17B10MAPT | |
| SCHEMBL9952327 | 0.76 | ELANE (0.45) | ELANEPOLBKDM4EHSD17B10F2 | |
| SCHEMBL3518373 | 0.76 | ELANE (0.50) | ELANEL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL14738967 | 0.75 | CPT1A (0.36) | ELANEPOLBMEN1KMT2AMAPT | |
| SCHEMBL15792144 | 0.74 | ADORA2A (0.39) | POLBKDM4EL3MBTL1HSD17B10MEN1 | |
| SCHEMBL14738410 | 0.74 | CA12 (0.41) | ELANEKDM4EHSD17B10HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | Merck Serono S.A. (CH) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |