SCHEMBL995308

SCHEMBL995308

O=C=NC1=CC=C(c2ccc(N=C=O)cc2)CC1(Cl)Cl

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1907184 0.82 CYP3A4 (0.36) CYP3A4TSHRMAPK1TDP1
SCHEMBL3133217 0.78 CYP3A4 (0.33) CYP3A4TSHRTDP1
SCHEMBL3787610 0.77 CYP3A4 (0.33) CYP3A4TSHR
SCHEMBL23721668 0.68 CYP3A4 (0.61) CYP3A4TSHRMAPK1TDP1
SCHEMBL241534 0.68 CYP3A4 (0.61) CYP3A4TSHRMAPK1TDP1
Water SCHEMBL3898007 0.66 CYP3A4 (0.58) CYP3A4TSHRMAPK1TDP1
Hydrogen Sulfide SCHEMBL3894665 0.66 CYP3A4 (0.58) CYP3A4TSHRMAPK1TDP1
SCHEMBL15430 0.65 CYP3A4 (0.70) CYP3A4TSHRMAPK1TDP1
Cyclohexane SCHEMBL1006843 0.63 CYP3A4 (0.61) CYP3A4TSHRMAPK1TDP1
SCHEMBL11551012 0.63 TDP1 (0.52) CYP3A4TSHRMAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0627452-B1 UV-absorbing polyurethanes and polyesters CIBA GEIGY AG (CH) 1998-12-09 EP claimed
EP-0507727-B1 Glass coating with improved adhesion and weather resistance CIBA GEIGY AG (CH) 1997-01-22 EP claimed
EP-0362145-B1 Crosslinked siloxane-urethane polymer contact lens CIBA GEIGY AG (CH) 1996-01-03 EP claimed
US-5480946-A CONTACT LENSES CIBA GEIGY CORPORATION (US) 1996-01-02 US claimed
US-5459222-A UV-absorbing polyurethanes and polyesters CIBA-GEIGY CORPORATION 1995-10-17 US claimed
US-5426158-A Interpenetrating polymer network with vinyl polymer CIBA-GEIGY CORP. (US) 1995-06-20 US claimed
EP-0627452-A1 UV-absorbing polyurethanes and polyesters CIBA-GEIGY AG (CH) 1994-12-07 EP claimed
US-5334681-A High oxygen permeability; resiliency, flexibility; wettability; biocompatibility CIBA-GEIGY CORPORATION (US) 1994-08-02 US claimed
EP-0367720-B1 Novel polysiloxane-polyurethanes and contact lenses thereof CIBA GEIGY AG (CH) 1994-07-20 EP claimed
EP-0455585-B1 Unsaturated urea polysiloxanes CIBA GEIGY AG (CH) 1994-03-23 EP claimed
EP-0507727-A2 Glass coating with improved adhesion and weather resistance CIBA-GEIGY AG (CH) 1992-10-07 EP claimed
US-5115056-A FLUORINE AND/OR SILICONE CONTAINING POLY(ALKYLENE-OXIDE)-BLOCK COPOLYMERS AND CONTACT LENSES THEREOF CIBA-GEIGY CORPORATION (US) 1992-05-19 US claimed
US-4983702-A Crosslinked siloxane-urethane polymer contact lens CIBA-GEIGY CORPORATION (US) 1991-01-08 US claimed
US-4962178-A 0XYGEN PERMEABLE MEMBRANE CIBA-GEIGY CORPORATION (US) 1990-10-09 US claimed
EP-0367720-A2 Novel polysiloxane-polyurethanes and contact lenses thereof CIBA-GEIGY AG (CH) 1990-05-09 EP claimed
EP-0362145-A2 Crosslinked siloxane-urethane polymer contact lens CIBA-GEIGY AG (CH) 1990-04-04 EP claimed
EP-1648534-B2 ANTIMICROBIAL MEDICAL DEVICES NOVARTIS AG (CH) 2018-11-14 EP disclosed
US-9612455-B2 Extended wear ophthalmic lens NOVARTIS AG (CH) 2017-04-04 US disclosed
EP-0109355-A1 Silicon-containing polymers having an increased oxygen permeability CIBA-GEIGY AG (CH) 1984-05-23 EP disclosed
US-4255551-A EXTRUDING WITH A SOLID HYDROXYL GROUP-CONTAINING POLYESTER, COOLING, MILLING, SCREENING; STORAGE STABILITY CHEMISCHE WERKE HULS AG (DE) 1981-03-10 US disclosed