Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.70 |
| ▸ | JAK1 | P23458 | 19/20 | 0.70 |
| ▸ | JAK3 | P52333 | 9/20 | 0.58 |
| ▸ | TYK2 | P29597 | 3/20 | 0.58 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | PRKCA | P17252 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953086 | 1.00 | JAK2 (0.70) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL9953151 | 0.88 | JAK2 (0.70) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL12385265 | 0.82 | JAK2 (1.00) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL2224385 | 0.82 | JAK2 (1.00) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL2224389 | 0.82 | JAK2 (1.00) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL10281490 | 0.81 | JAK1 (0.70) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL10281507 | 0.81 | JAK1 (0.65) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL9953298 | 0.81 | JAK1 (0.65) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL2275263 | 0.81 | JAK1 (0.76) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL2275257 | 0.81 | JAK1 (0.76) | JAK2JAK1JAK3TYK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |