Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952743 | 0.89 | JAK1 (0.80) | JAK1JAK2 | |
| SCHEMBL10281520 | 0.89 | JAK1 (0.58) | JAK1JAK2 | |
| SCHEMBL2278208 | 0.88 | JAK1 (0.79) | JAK1JAK2 | |
| SCHEMBL10282020 | 0.87 | JAK1 (0.74) | JAK1JAK2 | |
| SCHEMBL9953315 | 0.87 | JAK1 (0.74) | JAK1JAK2 | |
| SCHEMBL2292816 | 0.86 | JAK1 (1.00) | JAK1JAK2 | |
| SCHEMBL9953440 | 0.86 | JAK1 (0.73) | JAK1JAK2 | |
| SCHEMBL10281496 | 0.86 | JAK1 (0.78) | JAK1JAK2 | |
| SCHEMBL10282019 | 0.86 | JAK1 (0.78) | JAK1JAK2 | |
| SCHEMBL9953870 | 0.83 | JAK1 (0.73) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |