SCHEMBL99533

SCHEMBL99533

COc1cc(NC(=O)CCCc2ccc(-c3ccccc3)c(NC(=O)OC3CC4CC[C@H](C3)[N+]4(C)C)c2)c(Cl)cc1C=O

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 11/20 0.39
ADRB2 P07550 10/20 0.39
CHRM2 P08172 2/20 0.39
CHEK1 O14757 1/20 0.38
HPGD P15428 2/20 0.37
POLB P06746 1/20 0.36
CHRM1 P11229 1/20 0.35
APOBEC3A P31941 1/20 0.34
APOBEC3G Q9HC16 1/20 0.34
TRPV1 Q8NER1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodide SCHEMBL661449 0.91 CHRM3 (0.37) CHRM3ADRB2CHRM2CHEK1HPGD
Iodide SCHEMBL100439 0.90 CHRM3 (0.41) CHRM3ADRB2CHRM2CHEK1HPGD
Iodide SCHEMBL99407 0.90 CHRM3 (0.42) CHRM3ADRB2CHRM2CHEK1HPGD
Iodide SCHEMBL662438 0.89 CHRM3 (0.37) CHRM3ADRB2CHRM2CHEK1HPGD
Iodide SCHEMBL100739 0.88 CHRM3 (0.41) CHRM3ADRB2CHRM2CHEK1HPGD
Iodide SCHEMBL98952 0.85 CHRM3 (0.42) CHRM3ADRB2CHRM2CHEK1HPGD
Iodide SCHEMBL98962 0.84 CHRM3 (0.41) CHRM3ADRB2CHRM2CHEK1HPGD
SCHEMBL15823257 0.84 POLB (0.45) CHEK1HPGDPOLBTRPV1
Iodide SCHEMBL100336 0.83 CHRM3 (0.38) CHRM3ADRB2CHRM2CHEK1
Iodide SCHEMBL99848 0.81 CHRM3 (0.40) CHRM3ADRB2CHRM2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2426121-A1 QUATERNARY AMMONIUM SALT COMPOUND Teijin Pharma Limited (JP) 2012-03-07 EP claimed