Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952839 | 0.92 | PIK3CD (0.34) | PIK3CDHIF1AAURKANTRK1 | |
| SCHEMBL9952134 | 0.90 | PIK3CD (0.43) | PIK3CDCYP3A4CYP1A2CYP2C19CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL9951953 | 0.87 | PIK3CD (0.41) | PIK3CDCYP3A4CYP1A2CYP2C19CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL9952120 | 0.86 | PIK3CD (0.37) | PIK3CDCYP3A4CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL9929308 | 0.84 | PIK3CD (0.47) | PIK3CD | |
| SCHEMBL9953057 | 0.78 | PIK3CD (0.44) | PIK3CD | |
| SCHEMBL9928749 | 0.76 | PIK3CD (0.38) | PIK3CD | |
| SCHEMBL9928933 | 0.75 | PIK3CD (0.43) | PIK3CDCYP3A4 | |
| SCHEMBL9967867 | 0.75 | PIK3CD (0.40) | PIK3CDCYP3A4 | |
| SCHEMBL9953118 | 0.75 | CYP1A2 (0.37) | PIK3CDCYP3A4CYP1A2CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |