Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955097 | 0.92 | KDR (0.49) | KDRMAOBGRM5PDGFRBEGFR | |
| SCHEMBL9954960 | 0.86 | MAOB (0.54) | KDRMAOBGRM5PDGFRBFYN | |
| SCHEMBL9955805 | 0.86 | PDGFRB (0.56) | KDRMAOBGRM5PDGFRBEGFR | |
| SCHEMBL9955589 | 0.86 | KDR (0.51) | KDRMAOBGRM5PDGFRBEGFR | |
| SCHEMBL9956030 | 0.85 | KDR (0.52) | KDRMAOBGRM5PDGFRBEGFR | |
| SCHEMBL9955625 | 0.83 | KDR (0.51) | KDRMAOBGRM5PDGFRBEGFR | |
| SCHEMBL9955942 | 0.83 | KDR (0.51) | KDRMAOBGRM5PDGFRBEGFR | |
| SCHEMBL9954917 | 0.82 | KDR (0.52) | KDRMAOBGRM5PDGFRBEGFR | |
| SCHEMBL9960542 | 0.82 | KDR (0.53) | KDRMAOBGRM5PDGFRBEGFR | |
| SCHEMBL9956369 | 0.81 | KDR (0.51) | KDRMAOBGRM5PDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |