Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1918337 | 0.95 | ATM (0.40) | ATML3MBTL1RCE1LMNACYP19A1 | |
| SCHEMBL2297611 | 0.90 | ATM (0.43) | ATML3MBTL1IKBKBRCE1LMNA | |
| SCHEMBL1919350 | 0.87 | KDM4E (0.39) | LMNACYP19A1ANO1F2KDM4E | |
| SCHEMBL1919537 | 0.86 | ANO1 (0.43) | CYP19A1ANO1MEN1KMT2AKDM4E | |
| SCHEMBL3533863 | 0.86 | KDM4E (0.47) | L3MBTL1RCE1MEN1KMT2AMAPT | |
| SCHEMBL2363613 | 0.85 | CYP2C9 (0.43) | — | |
| SCHEMBL2844773 | 0.85 | CYP19A1 (0.37) | CYP19A1ANO1ALDH1A1PTGS2 | |
| SCHEMBL1918630 | 0.85 | CYP19A1 (0.37) | CYP19A1ANO1F2ACLYPTGS2 | |
| SCHEMBL29950180 | 0.85 | CYP2C9 (0.43) | — | |
| SCHEMBL2835706 | 0.82 | CYP3A4 (0.36) | CYP19A1ANO1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655362-A1 | HEPATITIS C INHIBITORS AND USES THEREOF | Abbvie Inc. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087833-A1 | HEPATITIS C INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2012-06-28 | — | — | WO | disclosed |