Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.49 |
| ▸ | JAK2 | O60674 | 8/20 | 0.49 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279617 | 1.00 | JAK1 (0.49) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL2274345 | 0.95 | JAK1 (0.46) | JAK1JAK2JAK3TYK2USP30 | |
| SCHEMBL2274218 | 0.93 | JAK1 (0.49) | JAK1JAK2JAK3TYK2PIK3CA | |
| SCHEMBL2275417 | 0.92 | JAK1 (0.48) | JAK1JAK2JAK3TYK2PIK3CA | |
| SCHEMBL2277381 | 0.88 | JAK1 (0.47) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL2275215 | 0.87 | JAK1 (0.45) | JAK1JAK2JAK3TYK2USP30 | |
| SCHEMBL2280324 | 0.86 | JAK1 (0.45) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL2280395 | 0.84 | JAK2 (0.43) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2283403 | 0.83 | JAK1 (0.43) | JAK1JAK2JAK3TYK2USP30 | |
| SCHEMBL2273150 | 0.82 | JAK1 (0.49) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |